Role of type-specific neuron properties in a spinal cord motor network |
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Authors: | Bart Sautois Stephen R Soffe Wen-Chang Li Alan Roberts |
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Institution: | (1) Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281-S9, B-9000 Ghent, Belgium;(2) School of Biological Sciences, University of Bristol, Bristol, BS8 1UG, UK |
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Abstract: | Recent recordings from spinal neurons in hatchling frog tadpoles allow their type-specific properties to be defined. Seven
main types of neuron involved in the control of swimming have been characterized. To investigate the significance of type-specific
properties, we build models of each neuron type and assemble them into a network using known connectivity between: sensory
neurons, sensory pathway interneurons, central pattern generator (CPG) interneurons and motoneurons. A single stimulus to
a sensory neuron initiates swimming where modelled neuronal and network activity parallels physiological activity. Substitution
of firing properties between neuron types shows that those of excitatory CPG interneurons are critical for stable swimming.
We suggest that type-specific neuronal properties can reflect the requirements for involvement in one particular network response
(like swimming), but may also reflect the need to participate in more than one response (like swimming and slower struggling).
Action Editor: Eberhard E. Fetz |
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Keywords: | Tadpole model Swimming CPG Type-specificity NMDA |
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