Possible use of ail and foxA polymorphisms for detecting pathogenic Yersinia enterocolitica |
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| Authors: | Ying Huang Xin Wang Zhigang Cui Yuhuan Yang Yuchun Xiao Liuying Tang Biao Kan Jianguo Xu Huaiqi Jing |
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| Affiliation: | (1) National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, 102206 Beijing, China;(2) Fujian Provincial Centre for Disease Control and Prevention, 350001 Fuzhou, China;(3) National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 100052 Beijing, China |
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| Abstract: | Background Yersinia enterocolitica is an enteric pathogen that invades the intestinal mucosa and proliferates within the lymphoid follicles (Peyer's patches). The attachment invasion locus (ail) mediates invasion by Y. enterocolitica and confers an invasive phenotype upon non-invasive E. coli; ail is the primary virulence factor of Y. enterocolitica. The ferrioxamine receptor (foxA) located on the Y. enterocolitica chromosome, together with its transport protein, transports a siderophore specific for ferric ion. Currently, ail is the primary target gene for nucleic acid detection of pathogenic Y. enterocolitica. |
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