Bruce Merrifield and solid-phase peptide synthesis: a historical assessment |
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Authors: | Mitchell Alexander R |
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Affiliation: | Lawrence Livermore National Laboratory, 7000 East Avenue, L-282, Livermore, CA 94550, USA. mitchell4@llnl.gov |
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Abstract: | Bruce Merrifield, trained as a biochemist, had to address three major challenges related to the development and acceptance of solid-phase peptide synthesis (SPPS). The challenges were (1) to reduce the concept of peptide synthesis on a insoluble support to practice, (2) overcome the resistance of synthetic chemists to this novel approach, and (3) establish that a biochemist had the scientific credentials to effect the proposed revolutionary change in chemical synthesis. How these challenges were met is discussed in this article. |
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