Role of RpoH, a heat shock regulator protein, in Escherichia coli carbon starvation protein synthesis and survival. |
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Authors: | D E Jenkins E A Auger A Matin |
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Affiliation: | Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305-5402. |
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Abstract: | Escherichia coli starvation proteins include several heat shock proteins whose induction by heat is controlled by the minor sigma factor, sigma 32. The level of sigma 32 increased in wild-type E. coli upon starvation, and three sigma 32-controlled heat shock proteins (DnaK, GroEL, and HtpG) were not induced during starvation in an isogenic delta rpoH strain, which is unable to synthesize sigma 32. Thus, sigma 32 plays a role in the induction of these proteins during both heat shock and starvation. The delta rpoH strain was more sensitive to starvation but could develop starvation-mediated cross protection against heat and oxidation. |
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