Bound acetyl cholinesterase in the central nervous system of Acheta domesticus (L.) (Orthoptera) |
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| Authors: | J S Edwards D Gomez |
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| Affiliation: | 1. Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;2. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;3. Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Ave., New York, NY 10065, USA |
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| Abstract: | Three of eight esterases separable by acrylamide gel electrophoresis of homogenates of central nervous tissue from Acheta domesticus are true acetyl cholinesterases as determined by substrate preference and inhibition with eserine. A major portion of the three cholinesterases occurs in a form which is activated by treatment with the detergent Triton X-100. Triton X-100 has been shown to release bound hydrolases from vesicles, e.g. lysosomes, but in this case may be liberating acetyl cholinesterase from the cell surface where it has been demonstrated by recent electron microscope studies. |
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