High-density molecular map of the central span of the mouse X chromosome. |
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Authors: | N Brockdorff G Kay S Smith J T Keer R M Hamvas S D Brown S Rastan |
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Institution: | Section of Comparative Biology, MRC Clinical Research Centre, Harrow Middlesex, United Kingdom. |
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Abstract: | A total of 17 linking clones previously sublocalized to the central span of the mouse X chromosome have been ordered by detailed analysis through interspecific Mus spretus/Mus musculus domesticus backcross progeny. These probes have been positioned with respect to existing DNA markers utilizing a new interspecific backcross segregating for the Tabby (Ta) locus. The density of clones within this 11.5-cM interval is now, on average, one clone every 1000 kb. This high-density map provides probes in the vicinity of a number of important genetic loci in this region which include the X-inactivation center, the Ta locus, and the mottled (Mo) locus, and therefore provides a molecular framework for identification of the genes encoded at these loci. |
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