Elements in erythrocytes of population with different thyroid hormone status |
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Authors: | Nianqing Liu Pingsheng Liu Qing Xu Li Zhu Zhiying Zhao Zhenghua Wang Yanfen Li Weijing Feng Lianzhen Zhu |
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Affiliation: | (1) Institute of High Energy Physics, Chinese Academy of Sciences, 100039 Beijing, China;(2) Department of Nuclear Medicine, Peking Union Medical College (PUMC) Hospital, 100730 Beijing, China;(3) Department of Technical Physics, Peking University, 100871 Beijing, China;(4) Institute of Nutrition and Food Hygience, Chinese Academy of Preventive Medicine, 100051 Beijing, China |
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Abstract: | The contents of elements K, Ca, Fe, Cu, Zn, Se, and Rb in erythrocytes of 78 cases with different thyroid hormone status have been measured by proton-induced X-ray emission and neutron activation analysis. According to the status of thyroid hormones T3, T4, TSH, FT3, and FT4 detected by radioimmunoassay, the experiment subjects were divided into four groups (i.e., hyperthyroid, hypothyroid, critical [one of thyroid hormones was abnormal], and normal). Elements contents and hormones levels of four groups were analyzed by one-way analysis of variance and correlation using an SPSS/PC statistical package. The results showed that the Se contents of four groups were not significantly different (p<0.05). Zn content of hypothyroid group was significantly higher than those of hyperthyroid and critical groups. The Zn content of the normal group was higher than that of the hypothyroid group and lower than that of the hyperthyroid and critical groups. In the hyperthyroid group, there were significant correlations between elements contents and thyroid hormones levels (except TSH), but not between elements contents and levels of thyroid hormones. However, in the hypothyroid group, relatively strong correlations have been found between elements contents and thyroid hormones levels, especially between Zn and the T3/T4 ratio, and between Zn and TSH. |
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Keywords: | Elements thyroid hormones erythrocyte hypothyroidism proton-induced X-ray emission neutron activation analysis |
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