| 孕酮受体在雌性小鼠生殖系统中的分布及RU486对其影响 |
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| 引用本文： | 诸定寿,史小林,梁元晶,翁静,许晴,路欣. 孕酮受体在雌性小鼠生殖系统中的分布及RU486对其影响[J]. 中国组织化学与细胞化学杂志, 1997, 0(3) |
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| 作者姓名： | 诸定寿 史小林 梁元晶 翁静 许晴 路欣 |
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| 作者单位： | 首都医科大学生殖医学中心 |
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| 基金项目： | 国家自然科学基金，北京市自然科学基金 |
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| 摘 要： | 用免疫细胞化学ＬＳＡＢ法，兔抗人孕酮受体抗体（适用于小鼠）显示小鼠卵巢、输卵管、子宫和阴道中的孕酮受体。结果显示：未注射ＲＵ４８６的动物的子宫与阴道内孕酮受体丰富，输卵管中含量较少，卵巢中未见阳性反应物质。ＲＵ４８６注射４天后，子宫与阴道中孕酮受体明显减少；注射后７天，输卵管、子宫和阴道都为阴性反应。该结果显示了孕酮受体在雌性小鼠生殖系统内的分布特点，提示ＲＵ４８６封闭孕酮受体的最佳时间为用药后第７天。
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| 关 键 词： | 孕酮受体，雌性小鼠，生殖系统，免疫细胞化学，RU486 |
DISTRIBUTION OF PROGESTERONE RECEPTORS AND EFFECT OF RU486 IN FEMALE REPRODUCTIVE SYSTEM OF FEMALE MICE |
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| Zhu Dingshou,Shi Xiaolin,Liang Yuanjing,Weng Jing,Xu Qin,Lu Xin. DISTRIBUTION OF PROGESTERONE RECEPTORS AND EFFECT OF RU486 IN FEMALE REPRODUCTIVE SYSTEM OF FEMALE MICE[J]. Chinese Journal of Histochemistry and Cytochemistry, 1997, 0(3) |
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| Authors: | Zhu Dingshou Shi Xiaolin Liang Yuanjing Weng Jing Xu Qin Lu Xin |
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| Abstract: | Progesterone receptors in the ovaria, fallopian tubes, uteri and vaginas of female mice were studied by immunocytochemical LSAB method, using rabbit antihuman-progesterone-receptor IgG. In normal mice, progesterone receptors distributed mainly in uteri and vaginas, only a few in fallopian tubes, and none in ovaria. 4 days after the injection of RU486 the number of the receptors in uteri and vaginas reduced obviously. 7 days after injection, all tissues appeared negative reaction. This data showed the specific distribution of progesterone receptor in female mouse reproductive system and indicated that the best time for RU486 blocking progesterone receptor was the 7 th day after injection. |
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| Keywords: | Progesterone receptor Female mouse Reproductive system Immunocytochemistry RU486 |
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