Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors |
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| Authors: | Powell Noel A Clay Emma H Holsworth Daniel D Bryant John W Ryan Michael J Jalaie Mehran Zhang Erli Edmunds Jeremy J |
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| Affiliation: | Pfizer Global Research and Development, Michigan Laboratories, Ann Arbor, MI 48105, USA. noel.powell@pfizer.com |
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| Abstract: | We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold. |
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