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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
Affiliation:1. Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA;2. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA;3. Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;4. Metabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA;5. Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Abstract:
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  • Keywords:SLC4A7/NBCn1  mTOR signaling  bicarbonate metabolism  purine metabolism  pyrimidine metabolism
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