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Structural basis of SARM1 activation,substrate recognition,and inhibition by small molecules
Affiliation:1. Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia;2. Evotec (UK) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK;3. School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, QLD 4072, Australia;4. Disarm Therapeutics, a wholly-owned subsidiary of Eli Lilly & Co., Cambridge, MA, USA;5. Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Genetics, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA;6. Evotec SE, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany;7. Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Australia;8. Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Developmental Biology, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA
Abstract:
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  • Keywords:NADase  base exchange  TIR domain  ARM domain  orthosteric inhibitor  allosteric activator  cryo-EM  X-ray crystallography
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