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Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells
Affiliation:1. The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY 10021, USA;2. Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10021, USA;3. Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08903, USA;4. Molecular Cytogenetics Core Facility, Sloan Kettering Institute, New York, NY 10065, USA;5. Department of Biology, University of Iowa, Iowa City, IA 52242, USA;6. Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA;7. Department of Pediatric Hematology/Oncology, Rutgers University, New Brunswick, NJ 08903, USA
Abstract:
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  • Keywords:replication  fork stalling  DNA repair  fragile sites  mutagenesis  BRCA  MMBIR
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