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Structure and engineering of the minimal type VI CRISPR-Cas13bt3
Affiliation:1. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;2. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;3. McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;4. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;5. Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;6. Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan;7. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK;8. Structural Biology Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan;9. Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan;10. Inamori Research Institute for Science, 620 Suiginya-cho, Shimogyo-ku, Kyoto 600-8411, Japan
Abstract:
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  • Keywords:CRISPR-Cas  X-ray crystallography  cryo-EM  protein engineering  genome editing
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