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HIV integration in the human brain is linked to microglial activation and 3D genome remodeling
Affiliation:1. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;2. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;3. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;4. UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA;5. Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA;6. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;7. Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;8. Division of Infectious Diseases, Department of Medicine, Immunology Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Abstract:
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  • Keywords:human immunodeficiency virus  retrovirus  Hi-C  viral integration  microglia  single nuclei RNA-seq  HIV encephalitis  chromosomal conformations  microglia-neuron interactions  interferon
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