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RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation
Affiliation:1. Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702 USA;2. National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702 USA
Abstract:
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  • Keywords:BRAF  CRAF  cysteine-rich domain  CRD  autoinhibition  phosphatidylserine  RAS  RASopathies  RAF kinases  development
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