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CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency
Affiliation:1. State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Cell Biology, Tianjin Medical University, Qixiangtai Road 22, Tianjin 300070, China;2. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China;3. Translational Medical Center for Stem Cell Therapy, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Science and Technology, Shanghai Key Laboratory of Signaling and Disease Research, Tongji University, Shanghai 200092, China;4. Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark;5. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA;6. Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China;7. Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;8. Cell Biology Program and Center for Epigenetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA;9. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China;10. University of the Chinese Academy of Sciences, Beijing 100101, China;11. Tianjin Key Laboratory of Epigenetics for Organ Development of Premature Infants, Tianjin 300450, China
Abstract:
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  • Keywords:polycomb  CpG islands  demethylation  accessibility  post-implantation development  H3K27me3  H2AK119ub  H3K36me2  BRG1  SWI/SNF
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