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Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
Institution:1. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA;2. Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany;3. Structural Genomics Consortium, BMLS, Frankfurt am Main, Germany;4. Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt am Main, Germany;5. Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany;6. Department of Cell Biology, Harvard Medical School, Boston, MA, USA;7. Institute of Biophysics, Goethe University, Frankfurt am Main, Germany
Abstract:
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  • Keywords:CK1  casein kinase 1  protein kinase regulation  phosphoregulation  quantitative phosphoproteomics  structural biology
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