Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour |
| |
| Authors: | Watanabe Maria Angelica Ehara Nunes Sandra Odebrecht Vargas Nunes Sandra Odebrechet Vargas Amarante Marla Karine Guembarovski Roberta Losi Oda Julie Massayo Maeda Lima Kalil William Alves De Fungaro Maria Helena Pelegrinelli |
| |
| Institution: | (1) Physiology Laboratory, School of Biomedical Science, University of Liverpool, Liverpool, L69 3BX, England;(2) Department of Human Anatomy & Cell Biology, School of Biomedical Science, University of Liverpool, Liverpool, L69 3BX, England; |
| |
| Abstract: | Data suggest that the serotonin (5-hydroxytryptamine, 5-HT) system is implicated in the pathogenesis of multiple neuropsychiatric
disorders and may also be involved in smoking behaviour since nicotine increases brain serotonin secretion. It is known that
smoking behaviour is influenced by both genetic and environmental factors. The present review examines the role of the serotonin
transporter gene (5-HTT) in smoking behaviour and investigating studies that showed association of 5-HTT gene with smoking.
This study discusses a polymorphism which has been investigated by many researchers, as the bi-allelic insertion/deletion
polymorphism in the 5′- flanking promoter region (5-HTTLPR). This gene has received considerable attention in attempts to understand the molecular
determinants of smoking. Therefore, in the present study, the relationship between genetic polymorphism of serotonin transporter
in smoking behaviour is reviewed considering the interactive effect of genetic factors. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
