Radiation induced alterations in rabbit aortic prostacyclin formation |
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Authors: | H Sinzinger W Firbas M Cromwell |
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Institution: | 1. Atherosclerosis Research Group (ASF) at the Department of Medical Physiology, Austria;2. 1st Department of Anatomy, University of Vienna, Austria |
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Abstract: | Earlier studies have demonstrated very severe vascular lesions occuring after irradiation in human and experimental animals as well. We examined the rabbit aortic PGI2-formation using the platelet bioassay technique in one year aged rabbits after different irradiation doses and a time course. The findings demonstrate a signficant increase in prostacyclin formation, which might be due to the damage of endothelial cells. This stage is followed by a long lasting severe depression. This behaviour in addition demonstrates a dose dependent manner. The findings of a long lasting decrease in vascular PGI2-formation might contribute to the understanding of the high incidence of vascular lesions being found at the site of irradiation. |
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Keywords: | Reprint requests to: HS ASF A-1090 Vienna Schwarzspanierstr 17 |
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