Effect of Zinc Supplementation on the Status of Thyroid Hormones and Na,K, and Ca Levels in Blood Following Ethanol Feeding |
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Authors: | R Pathak D Dhawan A Pathak |
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Institution: | (1) Department of Physiology, Bhojia Dental College, Baddi, India;(2) Department of Biophysics, Panjab University, Chandigarh, India;(3) Department of Biotechnology, GGDSD College, Panjab University, Chandigarh, India |
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Abstract: | The influence of zinc (Zn) on the serum levels of triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH) and sodium (Na), potassium (K), and calcium (Ca) was evaluated following ethanol toxicity
to the rats. To achieve this, male Wistar rats (150–195 g) were given 3 ml of 30% ethanol orally, and zinc was given in the
form of zinc sulfate (227 mg/l) in their drinking water daily for 8 weeks. Ethanol feeding resulted in a slight decrease in T3 and T4 levels and a significant increase in thyroid-stimulating hormone concentration, which may be due to the direct stimulatory
effect of ethanol on thyroid. Interestingly, when zinc was given to these rats, all the above levels were brought quite close
to their normal levels, thus indicating the positive role of zinc in thyroid hormone metabolism. Serum Zn and Ca levels were
found to be reduced, but Na levels were raised upon ethanol feeding. Restoration of normal levels of these metals upon zinc
supplementation to ethanol fed rats confirms that zinc has potential in alleviating some of the altered thyroid functions
following ethanol administration. |
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