Selenoenzymes,Laboratory Parameters,and Trace Elements in Different Types of Thyroid Tumor |
| |
Authors: | Paweł Zagrodzki Fergus Nicol John R Arthur Marian Słowiaczek Stanisław Walas Halina Mrowiec Renata Wietecha-Posłuszny |
| |
Institution: | 1.Department of Food Chemistry and Nutrition,Collegium Medicum Jagiellonian University,Kraków,Poland;2.H. Niewodniczanski Institute of Nuclear Physics,Kraków,Poland;3.Vascular Health Division, Rowett Institute of Nutrition and Health,The University of Aberdeen,Aberdeen,UK;4.Third Department of General Surgery,Collegium Medicum Jagiellonian University,Kraków,Poland;5.Department of Analytical Chemistry, Faculty of Chemistry,Jagiellonian University,Kraków,Poland |
| |
Abstract: | This study was performed to investigate selenoenzyme activities and trace element concentrations in thyroid tissues, with
reference to other parameters routinely used to characterize thyroid function. This was to reveal relevant parameters as possible
additional markers of tumor grade, clinical course, and prognosis of thyroid disorders. The tissue samples were obtained during
surgical treatment (total or near total thyroidectomy) of 122 patients with different types of thyroid tumor. For most of
the investigated parameters in different groups of patients, we did not find statistically significant differences. In the
majority of cases, thyroid benign or malignant tumors were not accompanied by significant derangement of the gland selenoenzymes
and of either intrathyroidal or plasma concentration of selenium. Nevertheless, types I and II iodothyronine deiodinases were
the most promising (among selenoenzymes) targets for diagnoses and possibly therapy of thyroid tumors. Higher activities of
both enzymes in cases with Graves’ disease, as compared with other thyroid lesions, suggest their involvement in the pathogenesis
of this condition. Patients with struna nodosa had higher levels of thyroid Zn, Cu, and Pb as compared with papillary carcinoma
subjects and also a higher level of Cu than follicular carcinoma cases. The above diagnostics may play a similar role to some
of the general thyroid function indices, TSH, anti-TG, anti-TPO, and calcitonin, which can partially distinguish between various
thyroid tumors. In conclusion, some of selenium status markers, when accompanied with general parameters, and trace elements
can serve as factors with pathophysiologic relevance and be helpful in the identification of malignant disease. Multivariate
statistical methods should be employed to tackle a broad array of thyroid tumor diagnostic data in a short time. Partial least
squares model and other pattern recognition methods seem to be the most appropriate methods for that task. The miniaturization
of all the steps of complex analytical procedure should be developed in a way to allow its completion as sensitive, robust,
and efficient for use of the small quantity of material provided by fine-needle biopsy. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|