Transient phase kinetics of activation of human plasminogen |
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| Authors: | R. Varón A. Román F. García F. García Carmona |
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| Affiliation: | (1) Department of Chemistry, Universitarian Politechnic School of Albacete, University of Murcia, Spain;(2) Department of Biochemistry, Faculty of Medicine, University of Murcia, Spain |
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| Abstract: | Equations for the time-dependent concentrations of all species involved in the general mechanism of human plasminogen activation proposed by Wohlet al. (J. biol. Chem. 255, 2005–2013, 1980) have been derived. These equations are valid for the whole course of the reaction: for both the transient phase and the steady state. In addition, we compare our results with the ones obtained by the above-mentioned authors for the steady state assuming rapid equilibrium conditions. Finally, we propose a method for the determination of all velocity constants. |
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