Microtubule-organizing centres: a re-evaluation |
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Authors: | Lüders Jens Stearns Tim |
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Affiliation: | Department of Biological Sciences, Stanford University, CA 94305, USA. |
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Abstract: | The number, length, distribution and polarity of microtubules are largely controlled by microtubule-organizing centres, which nucleate and anchor microtubule minus ends in a process that requires gamma-tubulin. Here we discuss recent evidence indicating that gamma-tubulin-dependent formation of new microtubules is not restricted to conventional microtubule-organizing centres. These findings suggest that the spatio-temporal control of microtubule nucleation is more complex than previously thought, leading us to a re-evaluation of the concept of the microtubule-organizing center. |
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