Cholesterol in cerebrospinal fluid of brain tumor patients |
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| Authors: | Joseph H. Fleisher Laurence J. Marton Nicholas R. Bachur Richard S. Mann-Kaplan |
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| Affiliation: | Baltimore Cancer Research Center Baltimore, Maryland, USA |
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| Abstract: | A sensitive method for assay of total cholesterol (free plus esterified) in one ml of CSF is presented. Patients with brain tumors showed much higher levels of this sterol in CSF than those with neoplasia external to the central nervous system. Repeated assay of CSF cholesterol in post-surgical follow-up of brain tumor patients undergoing chemotherapy may provide a biochemical tool for detection of renewed tumor activity. |
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