Actions of morphine on prostate gland fructose metabolism |
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Authors: | John T Dombrosky John A Thomas Michael G Mawhinney John W Lloyd |
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Institution: | Department of Pharmacology, West Virginia University Medical Center, Morgantown, West Virginia 26506, USA |
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Abstract: | Varying doses of morphine sulfate (10, 20 or 40 mg/kg daily × 10) were observed to suppress metabolic activities in the mouse prostate gland. Prostate gland fructose, an index of androgenic activity, was significantly reduced by these dose regimes of morphine (P < 0.01). Injections of morphine sulfate (20 mg/kg daily × 10) led to an inhibitition in the synthesis of both fructose?14C and sorbitol?14C from glucose?14C by the prostate gland, part of which may have been due to decreased uptake of glucose by the gland. The assimilation of 2-deoxyglucose?14C by the prostate was also reduced by morphine treatment. The actions of morphine (2 × 10?3M) on the metabolism of radioactive glucose by the mouse prostate gland likewise revealed a significant reduction in the formation of sorbitol?14C, but no decrease in fructose?14C formation. These results indicate that both the and actions of morphine can inhibit fructose metabolism in the prostate gland. |
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Keywords: | Reprint requests should be addressed to Dr John A Thomas Department of Pharmacology West Virginia University Medical Center Morgantown West Virginia 26506 USA |
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