Pipecolic acid in the dog brain |
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| Authors: | Y Kasé M Kataoka T Miyata Y Okano |
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| Institution: | Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan |
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| Abstract: | Pipecolic acid is an intermdiary metabolite of lysine and is decarboxylated to produce piperidine, an endogenous synaptotropic substance. In the present study, the existence of pipecolic acid in the dog brain was confirmed. It was present in highest concentration in the cerebellum followed by the diencephalon and caudate nucleus, and this distribution resembles that of piperidine in dog brain. It seems to be evident that pipecolic acid is a precursor of piperidine in the brain. |
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