The effect of alpha- and beta-adrenergic antagonists of the self-stimulation phenomenon |
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Authors: | Lloyd Hastings Robert M Stutz |
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Institution: | Department of Psychology University of Cincinnati Cincinnati, Ohio 45220, USA |
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Abstract: | In an attempt to evaluate the possible existence of alpha- and/or beta- adrenergic components of the self-stimulation reward system, rats were injected (i.p.) with chlorpromazine hydrochloride (2.5 mg/kg), phentolamine hydrochloride (5 mg/kg), and propranolol hydrochloride (10 mg/kg). The alpha- adrenergic antagonists (chlorpromazine and pehntolamine) inhibited self-stimulation but the beta-adrenergic blocker (propranolol) was without significant effect. Self-stimulation is apparently mediated by the alpha-adrenergic system. |
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