Photoreactivation and repair replication in rat kangaroo cells |
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Authors: | D Krishnan RB Painter |
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Institution: | Laboratory of Radiobiology, University of California, San Francisco, Calif. 4122 U.S.A. |
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Abstract: | Potorous tridactylis cells can perform photoreactivation, i.e., the visible light- catalyzed reversal of UV-induced pyrimidine dimers in DNA. UV-induced inhibitions of total RNA and DNA synthesis can also be partially reversed by exposure to visible light. P. tridactylis cells can also perform repair replication, but the extent of the latter is reduced if the cells are exposed to visible light (VL). None of these effects are observed in mouse L cells, which cannot perform photoreactivation. The results are consistent with the concept of pyrimidine dimers are one of the main substrates for repair replication. |
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Keywords: | BUdr bromouracil deoxyriboside FUdR fluorouracil deoxyriboside HU hydroxyurea MEM minimal essential medium PR photoreactivation TdR thymidine VL visible light |
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