ZAP70 in chronic lymphocytic leukaemia |
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Authors: | Amin Shilu Parker Anton Mann Jelena |
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Affiliation: | Cell Signalling, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom. shilu.amin@ncl.ac.uk |
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Abstract: | The protein tyrosine kinase zeta-chain associated protein kinase (ZAP70), normally expressed in T cells and a subset of B cells, is solely expressed in poor prognosis chronic lymphocytic leukaemia and implicated in enhanced B cell receptor signalling. As a result, the expression of this protein provides an ideal prognostic marker for the disease. A previous study has shown differential CpG methylation of a 5' region of ZAP70 in leukaemic lymphoid cells, although no further epigenetic studies have been reported. Further investigation into the expression of ZAP70 may therefore provide targets for therapies. |
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