Involvement of membrane surface charge in thermal stability of the rat ovarian LH/hCG receptor |
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| Authors: | Scsuková S Jezová M Vranová J Kolena J |
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| Institution: | Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlárska 3, 833 06, Bratislava, Slovak Republic. |
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| Abstract: | Analysis of fluorescence of membrane-bound 8-anilino-1-naphthalene sulfonate and monodansylcadaverine probes revealed that a negative membrane surface charge derived from free fatty acids (FFA) resulted in destabilization of structure-functional properties of the rat ovarian LH/hCG receptor. Removal of FFA from rat luteal and porcine ovarian granulosa cells by BSA increased gonadotropin responsiveness of cells in cAMP formation. |
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