Adriamycin induced changes in translocation of sodium ions in transporting epithelial cells. |
| |
| Authors: | T N Solie C Yuncker |
| |
| Affiliation: | Departments of Physiology and Biophysics, and Chemistry Colorado State University Fort Collins, Colorado 80523, USA |
| |
| Abstract: | The antitumor, antibiotic, adriamycin stimulates the net transport of sodium ions across frog skin epithelium under short circuit conditions. This stimulation is largely independent of Ca++ concentration in the media or of previous treatment of the epithelium with amiloride, ouabain, and vasopressin. We believe adriamycin induces changes in membrane permeability to sodium ions and that such changes may explain, in part, the cardiotoxicity of this drug. |
| |
| Keywords: | Author to whom correspondence should be addressed. |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
