Characterization and ligand specificity of sheep IgG2 receptor |
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Authors: | Songlin Qiao Yanyan Yang Yunchao Liu Gaiping Zhang Jun Xi Hong Zhang Huifang Hao Xiaohui Tian Suzhen Yang Ruiguang Deng |
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Institution: | (1) College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China;(2) Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhenzhou, 450002, China;(3) Henan Academy of Agricultural Sciences, Zhenzhou, 450002, China |
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Abstract: | Neutrophils and macrophages in cattle express a novel class of immunoglobulin Fc receptor, specific for bovine IgG2, termed
boFcγ2R. In cows, the ability of neutrophils to kill immunoglobulin-opsonized microorganisms appears to depend largely on
this subclass. Although related to other mammalian FcγRs, boFcγ2R belongs to a novel gene family that includes the human killer
Ig-like receptor and FcαRI (CD89) proteins. In this study, we describe the presence and characterization of this novel class
of FcγR in sheep. The comparative analysis of this novel FcγR has allowed us to begin an exploration of some immunological
characteristic of ruminants.
The GenBank accession number of the nucleotide sequence reported here is EF541479 and FJ198054. |
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Keywords: | Cloning Expression Sheep IgG Fc Receptor |
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