Protein kinase C phosphorylates a component of NADPH oxidase of neutrophils |
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Authors: | Emanuele Papini Miroslawa Grzeskowiak Paolo Bellavite Filippo Rossi |
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Affiliation: | Istituto di Patologia Generale, Università degli Studi di Verona, Strada Le Grazie, 37134 Verona, Italy |
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Abstract: | A protein of 31.5 kDa belonging to the NADPH oxidase of neutrophils was phosphorylated following stimulation of the cells with phorbol myristate acetate. The same protein was phosphorylated in vitro in the presence ofcytosol and of Ca2+ and phosphatidylserine. The phosphorylation in vitro of the 31.5 kDa protein was increased by phorbol myristate acetate and was inhibited by trifluoperazine. The data are compatible with an involvement of protein kinase C in the activation of NADPH oxidase. NADPH oxidase Cytochrome b−245 Phosphorylation Protein kinase Neutrophil activation Respiratory burst |
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