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Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus |
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| Authors: | Christian Lood Martin Stenström Helena Tydén Birgitta Gullstrand Eva Källberg Tomas Leanderson Lennart Truedsson Gunnar Sturfelt Fredrik Ivars Anders A Bengtsson |
| Affiliation: | 1.Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Sölvegatan 23, 223 62 Lund, Sweden;2.Department of Clinical Sciences, Section of Rheumatology, Lund University and Skåne University Hospital, Kioskgatan 3, 221 85 Lund, Sweden;3.Department of Experimental Medical Science, Immunology Group, Lund University, Sölvegatan 19, 221 84 Lund, Sweden |
| Abstract: | IntroductionSystemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in many different organ systems, activation of leukocytes and production of pro-inflammatory cytokines. The heterodimer of the cytosolic calcium-binding proteins S100A8 and S100A9 (S100A8/A9) is secreted by activated polymorphonuclear neutrophils (PMNs) and monocytes and serves as a serum marker for several inflammatory diseases. Furthermore, S100A8 and S100A9 have many pro-inflammatory properties such as binding to Toll-like receptor 4 (TLR4). In this study we investigated if aberrant cell surface S100A8/A9 could be seen in SLE and if plasmacytoid dendritic cells (pDCs) could synthesize S100A8/A9. |
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