Codon usage divergence of homologous vertebrate genes and codon usage clock |
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Authors: | Manyuan Long John H Gillespie |
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Institution: | (1) Department of Genetics, University of California, 95616 Davis, CA, USA |
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Abstract: | Summary This paper is concerned with the divergence of synonymous codon usage and its bias in three homologous genes within vertebrate species. Genetic distances among species are described in terms of synonymous codon usage divergence and the correlation is found between the genetic distances and taxonomic distances among species under study. A codon usage clock is reported in alphaglobin and beta-globin. A method is developed to define the synonymous codon preference bias and it is observed that the bias changes considerably among species. |
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Keywords: | Codon usage molecular clock Genetic distance Vertebrate |
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