Tumor promoters and diacylglycerol activate the Na+/H+ antiporter of sea urchin eggs |
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| Authors: | A F Lau T C Rayson T Humphreys |
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| Affiliation: | 1. Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region (Ministry of Education), Guizhou University, Guiyang 550025, China;2. College of Animal Science, Guizhou University, Guiyang 550025, China;3. School of Marine Sciences, Ningbo University, Ningbo 315211, China |
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| Abstract: | Various tumor promoters (TPA, lyngbyatoxin and aplysiatoxin) and diacylglycerol induced cytoplasmic alkalinization of sea urchin eggs independently of intracellular Ca2+ release. This response stimulated protein synthesis and was blocked by amiloride or a lack of extracellular Na+, procedures which inhibit the Na+/H+ antiporter. These results suggest that the antiporter which is responsible for cytoplasmic alkalinization in sea urchin eggs is activated directly or indirectly by protein kinase C in a Ca2+-independent manner. |
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