Spirostanol glycosides from Agave cantala |
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| Affiliation: | 1. Drug Discovery Program, KCVA Medical Center, Midwest Veterans’ Biomedical Research Foundation, 4801 E. Linwood Blvd., Kansas City, MO 64128, United States;2. Neurology and Neurodegeneration Research lab, Kansas City Veterans Affairs Medical Center, 4801 E. Linwood Blvd., Kansas City, MO 64128, United States;3. Department of Computational Chemical Biology Core, Molecular Graphics and Modeling Core, University of Kansas, 2034 Becker Drive Lawrence, KS 66047, United States;4. UMKC School of Medicine, Department of Ophthalmology, 2411 Holmes Road, Kansas City, MO 64108, United States;5. Lab for Alzheimer''s Disease and Aging Research, Kansas City Veterans Affairs Medical Center and Departments of Neurology and Physiology, University of Kansas Medical School, 4801 E. Linwood Blvd., Kansas City, MO 64128, United States |
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| Abstract: | Two spirostanol glycosides, cantalasaponins -2 and -4 were isolated from the methanolic extract of the rhizomes of Agave cantala and were characterized. The first glycoside was found to be lethal against Biomphalaria glabrata, the snail vector of the disease schistosomiasis, at a concentration of 7 ppm. |
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