Two steroidal alkaloids from fritillaria harelinii |
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| Affiliation: | 2. Department of Phytochemistry, Nanjing College of Pharmacy, Nanjing, China;1. Department of Pharmacognosy, Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5 chome, Gifu 502, Japan;1. School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China;2. Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy, Yantai University, Yantai 264005, People’s Republic of China;3. School of Pharmaceutical Engineering, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China;4. Chinese People’s Liberation Army 967 Hospital, Dalian 116021, People’s Republic of China;1. Department of Horticultural Science, Tarbiat Modares University, Tehran, Iran;2. Research Institute of Forests and Rangelands, Tehran, Iran;3. Department of Agronomy and Plant Breeding, Faculty of Agriculture, University of Tehran, Karaj, Iran;1. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China;2. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China;3. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, PR China;1. Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi 830011, Xinjiang, PR China;2. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, Xinjiang, PR China;3. University of Chinese Academy of Sciences, Beijing 100039, PR China;1. Oregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland, Oregon, USA;1. College of Physics and Electronic Engineering, Northwest Normal University, Lanzhou 730070, China;2. Center for Quantum Science and Engineering, and Center for Advanced Study in Theoretical Sciences, Department of Physics, National Taiwan University, Taipei 10617, Taiwan;3. Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA |
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| Abstract: | Two new steroidal alkaloids named harepermine and hareperminside have been isolated from the bulbs of Fritillaria harelinii together with a known alkaloid, peiminine. The structure of the alkaloids were found to be 3β, 6β-dihydroxy-5α, 14α,17β-cevanine and its 3-O-glucoside on the basis of spectroscopic evidence. |
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