Binding of 1,2,3,4,6-pentagalloylglucose to proteins,lipids, nucleic acids and sugars

The binding of 1,2,3,4,6-pentagalloylglucose (PGG) to various proteins, lipids, nucleic acids, sugars and cultured human amniotic cells (FL cells) was examined quantitatively. The results indicate that PGG binds less to acidic than to neutral or basic proteins, but more to basic phospholipids than the other lipids, and also to nucleic acids and sugars. On the other hand, PGG bound to FL cells irreversibly and the antiherpetic or cytotoxic activity of PGG was inhibited in the presence of L-α-phosphatidylcholine or bovine serum albumin.