The Small Interfering RNA Pathway Is Not Essential for Wolbachia-Mediated Antiviral Protection in Drosophila melanogaster |
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| Authors: | Lauren M Hedges Ryuichi Yamada Scott L O'Neill Karyn N Johnson |
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| Affiliation: | School of Biological Sciences, The University of Queensland, Brisbane, Queensland, Australia. |
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| Abstract: | Wolbachia pipientis delays RNA virus-induced mortality in Drosophila spp. We investigated whether Wolbachia-mediated protection was dependent on the small interfering RNA (siRNA) pathway, a key antiviral defense. Compared to Wolbachia-free flies, virus-induced mortality was delayed in Wolbachia-infected flies with loss-of-function of siRNA pathway components, indicating that Wolbachia-mediated protection functions in the absence of the canonical siRNA pathway. |
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