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Evaluation of nucleolar organizer region-associated proteins in endometrial pathology.
Authors:M F Mauri  M L Fibbi  V Lo Re  M Albertoni  P Canevini
Affiliation:Department of Morbid Anatomy and Histopathology, Ospedale Civile Bollate, Italy.
Abstract:In the current study the argyrophil staining technique for NOR proteins (Ag-NORs) has been performed on cases of different endometrial lesions, trying to find an aid in differentiating atypical hyperplasia from well differentiated carcinoma in biopsy specimens. We conclude that the Ag-NOR count, even though in endometrial carcinoma is significantly exceeding that of atypical hyperplastic endometrium, could be a misleading discriminator, because of a wide overlap of values in individual cases.
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