TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase |
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Authors: | van Eijk Marco Scheij Saskia S van Roomen Cindy P A A Speijer Dave Boot Rolf G Aerts Johannes M F G |
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Institution: | Department of Medical Biochemistry, University of Amsterdam, Academic Medical Center, 1100 DE Amsterdam, The Netherlands. m.c.vaneijk@amc.uva.nl |
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Abstract: | Human chitotriosidase is specifically expressed by phagocytes, has anti-fungal activity towards chitin-containing fungi in vitro and in vivo, and is part of innate immunity. We studied the effect of toll-like receptor (TLR)- and nucleotide-binding oligomerization domain (NOD)-2 triggering on chitotriosidase expression and release by phagocytes. We find that TLR, but not NOD2 activation, regulates chitotriosidase release by neutrophils. Furthermore, both TLR and NOD2 activation resulted in diminished induction by monocytes. Lastly, NOD2 activation, but not TLR stimulation, induces chitinase expression in macrophages. We conclude that phagocyte-specific regulation is important for efficient eradication of chitin-containing pathogens. |
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Keywords: | AMCase acid mammalian chitinase AML acute myeloid leukemia m? macrophage MDP muramyl dipeptide NOD nucleotide-binding oligomerization domain pGN peptidoglycan TLR toll-like receptor |
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