Inhibition of carotenoid synthesis in Myxococcus fulvus (Myxobacterales) |
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Authors: | Hans Kleinig |
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Institution: | 1. Lehrstuhl für Zellbiologie, Institut für Biologie II der Universit?t Freiburg i. Br, Freiburg i. Br., Germany
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Abstract: | - The inhibitory effects of CPTA, nicotine, DPA, and San 6706 on carotenogenesis in Myxococcus fulvus were investigated.
- The effects of CPTA, D-nicotine, and L-nicotine were very similar. The action of the drugs wasadditive. The cyclization was inhibited at low doses, the introduction of the hydroxyl group at C-1′ at higher doses. Lycopene accumulated at high drug concentration. The mode of action of the inhibitors is discussed.
- In a carotenoid mutant of M. fulvus a stimulation of the “7,8-dehydrogenase” by CPTA was observed.
- The specific carotenoid content of bacteria was increased by DPA due to an enhanced formation of phytoene. At low doses of DPA small amounts of an intermediate carotenoid glucoside ester, a 7,8-dihydro derivative, were detected.
- DPA was taken up by the plasma membrane. Quantitative removal of DPA by washing was not possible.
- San 6706 specifically and reversibly blocked the desaturation of phytoene.
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