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Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis |
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| Authors: | Meng Charles Q Somers Patricia K Rachita Carolyn L Holt Lisa A Hoong Lee K Zheng X Sharon Simpson Jacob E Hill Russell R Olliff Lynda K Kunsch Charles Sundell Cynthia L Parthasarathy Sampath Saxena Uday Sikorski James A Wasserman Martin A |
| Institution: | AtheroGenics, Inc., 8995 Westside Parkway, GA 30004, Alpharetta, USA. cmeng@atherogenics.com |
| Abstract: | A series of novel phenolic compounds has been discovered as potent inhibitors of TNF-alpha-inducible expression of vascular cell adhesion molecule-1 (VCAM-1) with concurrent antioxidant and lipid-modulating properties. Optimization of these multifunctional agents led to the identification of 3a (AGI-1067) as a clinical candidate with demonstrated efficacies in animal models of atherosclerosis and hyperlipidemia. |
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