Chromosome abnormalities in early pregnancy analyzed by direct chromosome preparation of chorionic villi |
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| Authors: | Xianting Zhou Houshun Tong Sugui Wong Qien Shen Xuewen Fu Yingqi Cui |
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| Affiliation: | (1) Institute of Genetics, Academia Sinica, Medical University of Beijing, Beijing, People's Republic of China;(2) Gynecology and Obstetric Hospital, Medical University of Beijing, Beijing, People's Republic of China;(3) First Hospital, Medical University of Beijing, Beijing, People's Republic of China;(4) National Institute of Family Planning, Beijing, People's Republic of China;(5) Present address: Cytogenetics Laboratory, Pediatrics, North Shore University Hospital, 300 Community Drive, 11030 Manhasset, NY, USA |
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| Abstract: | Summary Chorionic villi chromosome analysis was performed on 1,186 cases of induced abortion between the 5th and 11th week of gestation. The total incidence of major chromosome abnormalitites, including numerical and structural chromosomal changes as well as mosaics and polyploids, was 4.5% (53 cases). The most common abnormalities were trisomy 21 (5 cases), trisomy 16 (4 cases), and monosomy X (4 cases). The incidence of chromosome abnormalities increased with the advancing age of the mother. |
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