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REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons
Authors:Anna Rocchi  Emanuele Carminati  Antonio De Fusco  Jagoda Aleksandra Kowalska  Thomas Floss  Fabio Benfenati
Affiliation:1. Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova Italy ; 2. IRCCS, Ospedale Policlinico San Martino, Genova Italy ; 3. Department of Experimental Medicine, University of Genova, Genova Italy ; 4. Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg Germany
Abstract:
Keywords:autophagy   mitochondria   neurons   oxidative stress   rapamycin   REST/NRSF   senescence   trehalose
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