Quantal analysis of synaptic processes in the neocortex |
| |
| Institution: | 1. Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China;2. School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;3. Department of Endocrinology, Jinzhou Medical University, Jinzhou 121001, China;4. Institute for Metabolic Disease, Fengxian Central Hospital Affiliated to Southern Medical University, Shanghai 226001, China;5. Department of Endocrinology, Xihua Xian People’s Hospital, Zhoukou 466000, China;6. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China;7. Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China;8. Department of Pathology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;9. Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing 400064, China;10. Department of Endocrinology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China;1. Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, United States;2. Department of Basic Medical Sciences, Western University of Health Sciences, Pomona, CA, United States |
| |
| Abstract: | The application of fluctuation analysis to studies of synaptic function in the neocortex is discussed. Analysis of failures of transmission has been valuable in indicating whether a presynaptic or a postsynaptic site is responsible for a change in synaptic efficacy. When combined with detailed ultrastructural verification of all synapses involved in an individual cell to cell connection, a reasonable estimate of quantal size and release probability under conditions of low frequency activity can be obtained. However, both the number of available release sites in functional terms and the probability that an action potential (AP) will release transmitter from any given site can vary from AP to AP at higher frequencies. A variety of presynaptic mechanisms that modulate release are now apparent. For example, one mechanism dominates release patterns at one class of connection which is insensitive to absolute firing frequency, but responsive to changes in frequency. At another class of connection, a different mechanism dominates, resulting in high sensitivity to frequency. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
