The influence of ethanol on the functional status of GABA(A) receptors |
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| Authors: | Golovko A I Golovko S I Leontieva L V Zefirov S Yu |
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| Institution: | (1) Regional Therapeutic and Diagnostic Medical Center  Bekhterev , Korabelnaya ul. 6, St. Petersburg, 198096, Russia;(2) West Virginia University, Box 9151, Morgantown, WV 26505-9151, USA |
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| Abstract: | Gamma aminobutyric acid (GABA) is one of the main inhibitory neurotransmitters in the mammalian brain. Its effects are realized via GABAA, GABAB, and GABAC receptors. GABAA is the most abundant type of GABA receptors. It consists of six classes of subunits,  ,  ,  ,  ,  , and  . Acute and chronic exposures to ethanol are accompanied by changes in structure and function of GABAA receptors. These changes may be a basis for altered behavior seen in alcoholism. |
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| Keywords: | GABA receptors ethanol subunits expression |
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