Hirsutane sesquiterpenoids from the marine-derived fungus Chondrostereum sp |
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| Authors: | Li Hou-Jin Lan Wen-Jian Lam Chi-Keung Yang Fen Zhu Xiao-Feng |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Sun Yat‐sen University, Guangzhou 510275, P.?R. China;2. School of Pharmaceutical Sciences, Sun Yat‐sen University, Guangzhou 510006, P.?R. China, (phone: +86‐20‐31859007;3. fax: +86‐20‐39943000);4. State Key Laboratory of Oncology in South China, Guangzhou 510060, P.?R. China |
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| Abstract: | A new hirsutane sesquiterpenoid, hirsutanol E (1), together with the known compounds hirsutanol A (2) and hirsutanol F (3; gloeosteretriol) were obtained from AcOEt extract of the marine fungus Chondrostereum sp., which was isolated from the soft coral Sarcophyton tortuosum. The structures were elucidated mainly on the basis of the NMR, MS, and X-ray single-crystal diffraction data. Hirsutanol A (2) exhibited potent cytotoxic activities against various cancer cell lines. |
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| Keywords: | Hirsutane sesquiterpenoids Sesquiterpenoids Chondrostereum species Sarcophyton tortuosum Hirsutanol E Soft corals Cytotoxic activity X‐Ray crystallography |
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