TRYPTOPHAN AND 5-HYDROXYTRYPTAMINE METABOLISM IN THE IMMATURE RAT BRAIN DURING RECOVERY FROM ASPHYXIA |
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| Authors: | M. D. Tricklebank F. J. Pickard J. Dobbing |
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| Affiliation: | Department of Child Health, The Medical School, University of Manchester, Oxford Road, Manchester M13 9PT, U.K. |
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| Abstract: | Abstract— The turnover of cerebral 5-HT in the 5-day-old rat during recovery from asphyxia was assessed in the brain by determining 5-hydroxyindoleacetic acid concentration, and by following the accumulation of 5-HT after inhibition of MAO. Marked increases in turnover were found to persist for up to 3 h after resuscitation and this increase was accompanied by increases in brain tryptophan, plasma total tryptophan and the fraction of the plasma total tryptophan that was not bound to albumin. None of these parameters were different from those in control animals 24 h after resuscitation. Brain and plasma tyrosine levels remained unaltered by the treatment at all times investigated. |
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